Ice formation is a fundamental challenge in the cryopreservation of cells, tissues, and other biological materials. During freezing and thawing, small ice crystals can grow into larger structures through a process known as ice recrystallization, contributing to cellular and structural damage that can negatively affect post-thaw recovery and function.
Ice Recrystallization Inhibitors, or IRIs, are compounds designed to limit this process by controlling the growth and recrystallization of ice. This approach offers a new way to address cryopreservation-induced damage and improve the preservation of sensitive biological materials.
This category of references explores the science of ice recrystallization inhibition and its potential applications across cell, tissue, and advanced therapy workflows. The research highlighted here examines how IRI technologies can complement existing cryopreservation strategies to support improved post-thaw recovery, quality, and function.