Cryopreservation - Journal Articles

2024 | Cryopreservation | Journal Articles

A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells

Authors: F.L.W.I., F., Q., K.W., Sin, Lee, Fong, Ram, Luah, W.X., Y.H., S.Y., R, Y.H., Jagannathan, Seng, Tan, J, Wu, N.S., M.S., J.H.L., Tucker-Kellogg, X., Teo, Soh, Sandikin, L., Raymond, J.J., D.B.L., S.Y., D., Birnbaum, Lim, Kairi, Chen, Cheung, M.E.

Published: Nature Biomeical Engineering, 2024;Jun 4

2024 | Cryopreservation | Journal Articles

CAR-T cell expansion platforms yield distinct T cell differentiation states

Authors: N., R., Highfill, R., Song, Jin, Underwood, S.L., Pouzolles, H.W., P., S., M., Prochazkova, Somerville, Black, Chou, M., R.P., M., H-C, Shao, Stroncek. D.F., Fellowes, Cheuk, A.T., L., Khan, V., Taylor, Traynor, J., Shi

Published: Cytotherapy, 2024;26:757-768

2024 | Cryopreservation | Journal Articles

CD81 and CD82 expressing tumor-infiltrating lymphocytes in the NSCLC tumor microenvironment play a crucial role in T-cell activation and cytokine production

Authors: H., YS, Lee, CY, Cho, Na, Kim Y, Hwang, JB, Yang, BC, K., Kim, JY, Lim, SM, Lee, JH, Kang, SM, Han, S., Jeon, SS, Hong, YJ, Kim, S., Baek, MH, Kim, MH, DK, Byeon, S, Pyo, Han, Kim, Y., Lee, KH

Published: Frontiers in Immunology, 2024;15:1336246

2024 | Cryopreservation | Journal Articles

Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias

Authors: Igoor, Kim, Foster, Chen, Jeyaprakash, T., F., Y., H.S., Q., Selvakumar, S., S.K., S.L., S., P., Lu, Kizana, Campbell, Ongtengco, Ni, D., Skelton, P.P., Reyes, Pearson, Leung, J., E., T., C.F.J., G., Clayton, R.J.P., Chong, L., L., H.H.L., Grieve, Tran, Kumar, Turnbull, Mulay, Z.E., Hing, J.J.H., George, Wilkie, Hume, S.M., V., S., S., O., Prowse, A., J., E., R.D., Palpant, Bennett, Gray, Wu, Gupta, McArthur, Tjahjadi, Dingwall, Paterson, Shah, Marcus, J.R., N.J., R., Z., A., L., S., H., H., A.D., Barry, Pathan, Kotake, Chiu, Nguyen

Published: Nature Cardiovascular Research, 2024;3:145–165

2024 | Cryopreservation | Journal Articles

Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium

Authors: L.T., R., V.M., K., A., Thakar, Dunlap, Goodman, Zhang, Moreland, Sakaue, Raychaudhuri, J., G., S.M., F., L.W., S., McDavid, Wagner, Firestein, Ekabe, Tabechian, Nathan, A., A., G.S., J.C., D., A, Rao, Meednu, Boyle, Jonsson, Pitzalis, ; Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network; Bykerk, S., D.A., V.P., N., D.L., A.H., C., Anolik, Brenner, Donlin, Wang, Holers, Wei, Filer, J.H., M.B.

Published: Nature Communications, 2024;15:4991

2024 | Cryopreservation | Journal Articles

EBV T-cell immunotherapy generated by peptide selection has enhanced effector functionality compared to LCL stimulation

Authors: M.A., G., J.D.M., S., Cooper, Graham, Barnett, Fraser, Hayes, R.S., G., M., A.R., A., Sutherland, McGowan, Mitchell, Zahra, C., N.W.A., D., S., Smith, Turner, McLean, Manchanayake, C., L.M., M.L., C., Vickers, Cowan, Campbell, Imlach

Published: Frontiers in Immunology, 2024;15:1412211

2024 | Cryopreservation | Journal Articles

Efficient generation of pancreatic progenitor cells from induced pluripotent stem cells derived from a non-invasive and accessible tissue source—the plucked hair follicle

Authors: J., Fatehi, Han, A., D., Sadat, Rogers, M., I.M., Fayyad, Taylor, M., D., Tang

Published: Cells 2024, 13, 1010

2024 | Cryopreservation | Journal Articles

Extracellular Vesicle Biogenesis of Three-dimensional Human Pluripotent Stem Cells in a Novel Vertical-Wheel Bioreactor

Authors: H., O., Muok, Vied, Driscoll, L., C., T., Sun, Duke, Jung, L., L., S., Esmonde, Ma, Li, Y., C., S., Worden, Zeng

Published: Journal of Extracellular Biology, 2024;3:e133

2024 | Cryopreservation | Journal Articles

Good manufacturing practice production of human corneal limbus-derived stromal stem cells and in vitro quality screening for therapeutic inhibition of corneal scarring

Authors: M.Y.S., D.K., Santra, Funderburgh, Jhanji, M., M.L., V. Hin‑Fai Yam, Geary, Chandran, G., M.L., C., Rubin, Du, E., Y., Hsu, Dhaliwal

Published: Stem Cell Research & Therapy, 2024;15:11

2024 | Cryopreservation | Journal Articles

Good Manufacturing Practice-compliant human induced pluripotent stemcells: from bench to putative clinical products

Authors: P.F., N., A., M., P., Novoa, Locher, Arendzen, Mummery, van der Valk, Wieles, J.J., H., C.H., C.L., W., Westra, van den Berg, Rajaei, Rabelink, Salvador, I.M., C.W., B., T.J., A., Steeneveld, Raymond, Grundeken, Freund, Carlotti, B., F., E., K.I., E., C., Dijkers, Fonseca Neves, Kirkeby, Yildiz, Meij

Published: Cytotherapy, 2024;26:556-566

2024 | Cryopreservation | Journal Articles

Improving cutaneous wound healing in diabetic mice using naturally derived tissue-engineered biological dressings produced under serum-free conditions

Authors: J., Safoine, M., Paquette, C., Gingras, G-M, Fradette

Published: Stem Cells International, 2024;3601101

2024 | Cryopreservation | Journal Articles

Inosine induces stemness features in CAR-T cells and enhances potency

Authors: L., L., J., B., S., Mackall, Davis, Klysz, Keerthi, Freitas, Gkitsas, Sandor, Asano, C.L., K.L., D.D., V., K.A., N., K., Satpathy, Fowler, Leruste, Chen, Guerrero, Xu, A.T., C., A., Y., J.A., P., Feldman, Malipatlolla, Bashti, Meier, Fisher, Huang, K., S.A., J., M., M., S., C., Sotillo, Patel, Labanieh, Stuani, Mata-Alcazar, Daniel, Patel, E., S.

Published: Cancer Cell, 2024;42: Issue 2: 266-282.e8

2024 | Cryopreservation | Journal Articles

Lentivirus-mediated BCL-XL overexpression inhibits stem cell apoptosis during ex vivo expansion and provides competitive advantage following xenotransplantation.

Authors: S., Zehnle, Erlacher, P.M.A., M., Wu, Y., Koleci, N., Bohler

Published: International Journal Molecular Science, 2024;25:7:4105

2024 | Cryopreservation | Journal Articles

Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial

Authors: L.M., M., E., V., Pant, Perry, Kasi, DeMuth, Basturk, S., J.R., P.M., P.C., O., Wainberg, Kheoh, Devoe, Haqq, VanWyk, Z.A., T., C.E., C.M., H., Weekes, McNeil, Leal, O’Reilly, Tavares, A.M., C.D., L.K., A.D., E.M., Seenappa, Furqan, Welkowsky, Chung

Published: Nature Medicine, 2024

2024 | Cryopreservation | Journal Articles

Micro-engineered heart tissues on-chip with heterotypic cell composition display self-organization and improved cardiac function

Authors: M., M.C., Cofiño-Fabres, Blauw, Passier, C., L., R., Boonen, Rensen, T., P.C.N., Rivera-Arbeláez, Schwach, J.M., V., Rijpkema, Ribeiro

Published: Advanced Healthcare Materials, 2024, 2303664

2024 | Cryopreservation | Journal Articles

Natural killer cells drive 4-1BBL positive uveal melanoma towards EMT and metastatic disease

Authors: L., Y., A., Neo, Wagner, Chen, Hui Teo, S.Y., A.K., Z., J.K., Oliveira, Westerberg, Cismas, Lam, M.M.S., L.S., S., K-P, Tong, Lundqvist, Burduli, Alici, E., L., A., N., Girnita, Chen, Malmerfelt

Published: Journal of Experimental Clinical Cancer Research, 2024;43:13

2024 | Cryopreservation | Journal Articles

Oral PD-L1 inhibitor GS-4224 selectively engages PD-L1 high cells and elicits pharmacodynamic responses in patients with advanced solid tumors

Authors: N., A.Y., L., Odegard, Deva, Nazareno, Dunbar, J.M., S., J., P.R., Othman, Yoon, Thai, A.A., O.K., D., Lin, Ling, Ang, E., K.W., J., Waldron, Wang, Lad

Published: Journal for Immunotherapy of Cancer, 2024;12:4:e008547

2024 | Cryopreservation | Journal Articles

PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy

Authors: C., I., Y., H., Davies, O’Neill, Iannitto, Biswas, D., O., M.L., D., Kamdar, Nussbaumer, Morton, Ndagire, S., O., C., S., Woolf, Hayday, Haque, Munonyara, M., R., A., Y., Gillett, Zlatareva, Wu, Martin

Published: Nature Cancer, 2024

2024 | Cryopreservation | Journal Articles

Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial

Authors: J., R., E.M., E.J., N.Y., Yarchoan, Rochestie, Yan, Csiki, Kagohara, M., S., J., I., L.T., Gane, Peters, Cooch, Weiner, Bartha, E.J., J., N., D.B., G., Marron, Connor, Shu, Perales-Puchalt, Northcott, J., T.U., J.T., D.H., A., Lyle, Perales-Linares, Jaffee, Fertig, Sardesai

Published: Nature Medicine, 2024;4:1044-1053

2024 | Cryopreservation | Journal Articles

Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation

Authors: C.H., O., L., Berjis, Sheppard, Johnson, Plachta, A., N.C., O., N., Muthumani, Finck, Scholler, D., A.V., J., Aguilar, Engel, Lanier, L.L., O.A., N.W., June, Pomp, Chen

Published: Nature Communications; 2024:15:3937

2024 | Cryopreservation | Journal Articles

Removal of TREX1 activity enhances CRISPR–Cas9-mediated homologous recombination

Authors: A., Karasu, Cullot, M.E., G., Toufektchan, Maciejowski, E., J., Chen, Corn, Y., J.E., Albertelli

Published: Nature Biotechnology, 2024

2024 | Cryopreservation | Journal Articles

Single-cell RNA-sequencing of virus-specific cellular immune responses in chronic hepatitis B patients

Authors: A., F., Hatje, Simo-Noumbissie, Baumert, K., P., T.F., Kam-Thong, Kumpesa, Pelletier, T., N., N., Giroud, Nilsson, Forkel, M., N., T., Saviano, Habersetzer

Published: Scientific Data, 2024;11:1:355

2024 | Cryopreservation | Journal Articles

Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis

Authors: B.Y., P., K., L., C.J., Boland, Reynolds, Chan, Thomas, Nieman, Samanta, Song, Smith, Sharova, G.M., K.L., PY, M.F., L.T., N., Y., N.P., Dougan, Villani, Sullivan, Slowikowski, Chen, Tantivit, Xu, Tirard, M., A-C, R.J., K., J.H., J., K.H., A., Hacohen, Khalili, Manakongtreecheep, Eisenhaure, Nasrallah, Jorgji, Ramesh, N., T., H., S., K., T., M., V., Juric, Li, Glasser, Arnold, Sen, Pelka, Zubiri, Pinto, D., B., R.

Published: Nature Medicine, 2024;30:1349–1362

2024 | Cryopreservation | Journal Articles

Sorbitol destroyed intestinal microfold cells (M Cells) development through inhibition of PDE4-mediated RANKL expression

Authors: L., W., R., Xiang, Gong, Xie, Huang, L., S., S., C., Pan, Xu, Liang, Luo, W., W., X., M., Chen, Zhao, Yang, Xu, Y., H., J., F., Geng, Du, Niu

Published: Mediators of Inflammation, 2024;7524314

2024 | Cryopreservation | Journal Articles

Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias

Authors: F.J., T., N., Wulkan, Laflamme, Kim, Weyers, F., M.A., K-P, J.J., Romagnuolo, Quesnel, Ghugre, R., E., N.R., Qiang, Jiang, Ozcan, B., B., W., Alibhai, Valdman Sadikov, Andharia

Published: Frontiers in Cardiovascular Medicine, 2024;11:1374881

2024 | Cryopreservation | Journal Articles

The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments

Authors: H., B., Y., Chen, Liu, Xia, T., R., B., Deng, Zhu, Lin, J., Y., K., Zhang, Zhou, Ma, X., Y., M., Zhang, Liu, Lin

Published: Molecular Cancer, 2024;23:53

2024 | Cryopreservation | Journal Articles

The effect of human PBMCs immobilization on their Аβ42 aggregates dependent proinflammatory state on a cellular model of Alzheimer’s disease

Authors: H., Kot, Tigunova, K., O., Kot, Blume, Y., Y. Shulga, Kurbanov, S., R., Andriiash

Published: Frontiers in Neuroscience, 2024:18:1325287

2024 | Cryopreservation | Journal Articles

The effect of SARS-CoV-2 infection and vaccination on Th17 and regulatory T cells in a pregnancy cohort in NYC

Authors: V., C., S., Gigase, de Witte, Rommel, Stone, FAJ, LD, AS, J., Graziani, Flores, Janevic, M., T., T., Castro, Perez-Rodriguez, Lieb, W., J., MM, Bergink, Lesseur, Dolan

Published: Frontiers in Immunology, 2024;15:1350288

2023 | Cryopreservation | Journal Articles

[68Ga]Ga-NODAGA-E[(cRGDyK)]2 and [64Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy

Authors: S., C.H., Follin, Juhl, Ripa, B., M., R.S., Hoeeg, Jensen, Kastrup, C., J.K., J.; Ekblond, Hunter, Binderup, A., and Kjaer, I., T., A., Bentsen, Nielsen

Published: Diagnostics, 2023:13:268.

2023 | Cryopreservation | Journal Articles

A clinically relevant large-scale biomanufacturing workflow to produce natural killer cells and natural killer cell-derived extracellular vesicles for cancer immunotherapy.

Authors: J. R., A., S., St-Denis-Bissonnette, Muradia, Burger, F., G., D., Cummings, Mehic, Lee, S. E., J., S.-H., Qiu, Mediratta, Wang, L., S., K., & Lavoie, Stalker, Kaczmarek

Published: Journal of Extracellular Vesicles, 2023; 12, e12387

2023 | Cryopreservation | Journal Articles

A high-throughput, high-containment human primary epithelial airway organ-on-chip platform for SARS-CoV-2 therapeutic screening

Authors: Zhang, RB, Medoff, LD, Fisher, C-H, Mulhern, BD, Marr, CR, Anderson, TJ, Borenstein, EE, Mba Medie, KS, Miller, JT, Vijayakumar. V, F., Jorgensen, CR, Gard, Gabriel, Luu, WL, Zhang, AL, EP, Quezada, RJ, Alladina, CJ, LL, Gaibler, JW, Rubio

Published: Cells, 2023;12(22):2639

2023 | Cryopreservation | Journal Articles

A highly efficient transgene knock-in technology in clinically relevant cell types

Authors: C.S., R., M., K.M., D., Nehil, Wilson, Mazzucato, Allen, Zhao, Lele, Wilson, Gerew, Nelson, M., C.J., P., A.G., A.H., S., A.C., A., Follit, Zuris, Huang, Khan, Sherman, Blaha, Sun, Pattali, J.A., J.A., Y., S.Q., S.E., L., X., R., Chang, Giannoukos, Margulies, Jaskolka, Scott, Ciulla, Cochran, K-H, J.D., G., N.R., C.M., M.C., S.N., D.M., Marco, Shearman, Zhang, Holland, Viswanathan, Wu, Izzo, Zhang, E., M.S., P.

Published: Nature Biotechnology, 2023

2023 | Cryopreservation | Journal Articles

A living ex vivo platform for functional, personalized brain cancer diagnosis

Authors: Hingtgen S, Valdivia A, Vaziri C, Mann B, Satterlee AB., Yang Y, Corcoran DL, Zhang X, Buckley A, Rego S, Bell N, Lettry V, Jiang Y, Adefolaju A, Quinsey C, Graves LM, Thang M, Rauf Y, Dunn D, Floyd S, Dasari R, Kram D, Baldwin A, Kanchi K, Cassidy N

Published: Cell Reports Medicine, 2023:4:101042

2023 | Cryopreservation | Journal Articles

A village in a dish model system for population-scale hiPSC studies

Authors: V., HS, GE, C., NJ, Neavin, Lam, Daniszewski, Graham, Chan, Powell, D.R., CE, MS, RM, C-L, Steinmann, Nguyen, Arora, Hewitt, Bax, A.M., U., H., AW, M., Farbehi, Hernández, Bermudez, Pébay, Tyebally, JE, M., N., D., Y., A., Gnanasambandapillai, Chiu, Lidgerwood, Moutinho, Palpant

Published: Nature Communication, 2023:14:3240

2023 | Cryopreservation | Journal Articles

Automated production of gene-modified chimeric antigen receptor T cells using the Cocoon Platform

Authors: H., K., MJ, R., Trainor, Gal Malka, Hails, Smith, Densham, N., R., L., T., P., Purpura, Rodin, Vicentini-Hogan, Leonard, Gardin, KA, A., M., D., P., Middleton, Ogen, McRobie, Bryan, Fouks, M., K., T., C., A., Brayer, Fargo, Besser, Daniels

Published: Cytotherapy, 2023;000:1-12

2023 | Cryopreservation | Journal Articles

Automated production of gene-modified chimeric antigen receptor T cells using the Cocoon Platform

Authors: H., K., MJ, R., Trainor, Malka, Hails, Smith, Densham, N., RG, L., T., P., Purpura, Rodin, Vicentini-Hogan, Leonard, Gardin, KA, A., M., D., P., Middleton, Ogen, McRobie, Bryan, Fouks, M., K., T., C., A., Brayer, Fargo, Besser, Daniels

Published: Cytotherapy, 2023;Volume 25, Issue 12:1349-1360

2023 | Cryopreservation | Journal Articles

Bioengineered tissue and cell therapy products are efficiently cryopreserved with pathogen‑inactivated human platelet lysate‑based solutions

Authors: B., F. and Santos‑González, Martín-López, Jimenez, M., M., R., Rosell-Valle, Nogueras, C., S., Arribas-Arribas, García‑Delgado, B., A.B., Fernández‑Muñoz, Campos

Published: Stem Cell Research & Therapy, 2023:14:69

2023 | Cryopreservation | Journal Articles

Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial

Authors: J., A., J., P., V., Mautner, Jensen, Bae, Mason, Chung, Yeago, K., K., WC, RA, CB, Gottschalk, Kippner, Black, Noonan, Easley, M., L., L., B., KA, Boden, Kurtenbach, Boggess, Roy, Gibson, C., G., S.D., C., B., K., Drissi, Hackel, Akard, Kurtzberg, Chatterjee, Valentine, H.

Published: Nature Medicine, 2023

2023 | Cryopreservation | Journal Articles

Cooperative CAR targeting to selectively eliminate AML and minimize escape

Authors: X., F., MR, Haubner, Rivière, Chang, Fraser, S., I., Q., K., Mansilla-Soto, Sadelain, de Stanchina, Subklewe, J., M., E., M., Nataraj, Lopez, Park, JH, S., M., Wang, Kogel, Ng

Published: Cancer Cell. 2023; Nov 13;41(11):1871-1891.e6

2023 | Cryopreservation | Journal Articles

Cryopreservation of human embryonic stem cell-derived retinal pigment epithelial cells at the optimal stage

Authors: X., X., Bai, Liu, X., H., Zhang, Ding, T., X., Zhu, Jiang, X., M., Huang, Sun

Published: Journal of Visualized Experiments, 2023;Nov 3;(201)

2023 | Cryopreservation | Journal Articles

Determinants of astrocytic pathology in stem cell models of primary tauopathies.

Authors: Fiock, KL, Hook, JN & Hefti, MM.

Published: Acta Neuropathologica Communications, 2023;11, 161

2023 | Cryopreservation | Journal Articles

Drug regulatory-compliant validation of a qPCR assay for bioanalysis studies of a cell therapy product with a special focus on matrix interferences in a wide range of organ tissues

Authors: C., Niebergall-Roth, Frank, E., M.H., Norrick, Kluth, A., M.A, Esterlechner, J., Ganss

Published: Cells 2023, 12, 1788

2023 | Cryopreservation | Journal Articles

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

Authors: J., E-H, J.C., M., A., Carpenter, A., M.C., Small, B.K., Wieder, Clish, Brown, Therrien, Kost-Alimova, Subramanian, A., Claussnitzer, J., Choudhary, N., C., M.R., M., M., E., M., Sreekanth, A., Coraor Fried, Shafqat Abbasi, Marshall, Yoon, Sieber, Shaw, Flannick, Sheu, V., J., H., J.L., H., J., J.L., J., E., Han, Kim, Singh, Arevalo, Lai, Gabriel, Pablo, Finucane, R., Stevens, M., K.R., C., S., C., Z.W., Lim, J.L., H., Devkota, B., Pacheco, Sidhom, Rutter, Dvela-Levitt, Baublis, D., Greka, Haigis, R., Wagner

Published: Cell Metabolism, 2023:35:887–905

2023 | Cryopreservation | Journal Articles

Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease.

Authors: G., K.O., H., Fear, Lassmann, Mantegna, Szappanos, V.S., T., J.L., H.C., Forbes, Htun, Hool, C.A., J.P., L., Shaw, Syn, Ward, M., N.C., G., Baynam, Farley, Viola

Published: Stem Cell Research & Therapy, 2023; 14:345

2023 | Cryopreservation | Journal Articles

GRT-R910: a self-amplifying mRNA SARSCoV-2 vaccine boosts immunity for ≥6 months in previously-vaccinated older adults

Authors: Garbes P, Gitlin L, Nganje CN, Palmer CD, Jooss K, Klein J, Bae K, Scallan CD, Ustianowski A., Davis MJ, Yan T, Kraemer Tardif LD, Venkatraman H, Leodones K, Kachura MA, Hart MG, Egorova M, Rappaport AR, Jaroslavsky JR, Hong SJ, Kuan J, Koralek DO, Kounlavouth S, Grappi S, Uriel A, Marrali M

Published: Nature Communications, 2023 Jun 6;14(1):3274

2023 | Cryopreservation | Journal Articles

Human-induced pluripotent stem cell-derived ovarian support cell co-culture improves oocyte maturation in vitro after abbreviated gonadotropin stimulation

Authors: K., B., PRJ, AD, M., Klein, McCulloh, Piechota, Guzman, Potts, Chatterjee, Figueroa, Marcinyshyn, JU, DH, S., L, KS, PL, AB, Klatsky, Fernandez-Gonzalez, Marchante, Belchin, Rockwell, Tran, Sanchez, P., M-J, M., P., G., ND, M., Ordonez-Perez, Abittan, Giovannini, Smela, Aschenberger, Kelk, Barrachina, D., S., B., F., A., MP, C., DA, Ortiz, Kramme, Smith, Wiemer, Paulsen, Fortuna, Noblett, Forti, S., CC, T.

Published: Human Reproduction, 2023;, dead205

2023 | Cryopreservation | Journal Articles

In vitro modelling of local gene therapy with IL-15/IL-15Rα and a PD-L1 antagonist in melanoma reveals an interplay between NK cells and CD4+ T cells

Authors: K., T., M., Awad, Zeven, Salguero, R.M., K., G., De Vlaeminck, Ceuppens, Raes, Y., H., G., Meeus, Goyvaerts, Devoogdt, N., F., C., Breckpot, Ertveldt, Verdonck

Published: Scientific Reports, 2023;13:18995

2023 | Cryopreservation | Journal Articles

iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting

Authors: Wu, M., Hancock, Snyder, J., Hart, B., K.M., Walcheck, G., Shirinbak, Dixon, B., Khaw, S., K.J., M. Matson, Miller, Davis, A., J.S., Valamehr, Z., Bjordahl, B., Hosking, R.

Published: Journal for ImmunoTherapy of Cancer, 2023;11:e007280

2023 | Cryopreservation | Journal Articles

Manufacturing of CD34,HPC-enriched, high-purity mononuclear cell products from umbilical cord blood

Authors: Wynn, L., Wilson, M.G., Leonforte, C.

Published: Cell Tissue Bank, 2023: Feb 3

2023 | Cryopreservation | Journal Articles

Mutations in DARS2 result in global dysregulation of mRNA metabolism and splicing

Authors: M., Guang, Fatemi, S., A., O’Brien, Nemeth, BM, CL, Fine, AS, Ying

Published: Scientific Reports, 2023:13, 13042

2023 | Cryopreservation | Journal Articles

Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy

Authors: Bao, S., CL, Heath, P., Hundal, D., K., Heeringa, Medina, Ting, Conroy, Hunter, Puig-Saus, XR, Shao, Pan, JR, Nayak, J., Quach, Dalmas, K., E., M., A., T., C., Gros, K., Abril-Rodriguez, Z., Franzusoff, S., Chmielowski, BB, Ma, Vega-Crespo, Tunuguntla, Yi, Zhao, Sennino, A., McHugh, G., Yuen, A., Hoover, B., Nguyen, S., Y., A., R., MC, B., Griffith, C., Cherry, B., Mandl, J., Speiser, D., Saco, Chizari, Baselga-Carretero, Sandoval, Shieh, Peng, OL, Greer, G., Purandare, SJ, Said, DE, Xia, JD, S., I., O., S., C., H., S., Griffith, J., Wong, B., Ribas, S., Bethune, Lu, Perez-Garcilazo, Pilling, Foy, Moot, Jilani, Wang, M., Peabody, DJ, An, A., Jacoby, MT, W., I., MJ, SP, R.

Published: Nature, 2023

2023 | Cryopreservation | Journal Articles

NeuroLINCS Proteomics: Defining human-derived iPSC proteomes and protein signatures of pluripotency

Authors: J., V., L., L., Matlock, Finkbeiner, Dardov, Sareen, Banuelos, A.D., S., V., D., M., Vaibhav, Fraenkel, Manalo, Svendsen, Mandefro, V., E., D-M., C.N., B., Holewinski, Rothstein, Shelley, NIH NeuroLINCS Consortium & Van Eyk, Escalante-Chong, R., R., J., B., J.E., Li, Venkatraman, Thompson, Ornelas

Published: Nature Scientific Data, 2023:10:24.

2023 | Cryopreservation | Journal Articles

Nicotinamide-Expanded Allogeneic Natural Killer Cells with CD38 Deletion, Expressing an Enhanced CD38 Chimeric Antigen Receptor, Target Multiple Myeloma Cells

Authors: K., N., Y., D., Edri, Anderson, Berhani-Zipori, Rosenberg, A., KC, O., M, Ben-Haim, Hendel, Rifman, Simantov, N., A., J., R, Hailu, Pato, Cohen, Teru, H, A., A., S., Kurata, Brycman, Geffen, Yackoubov

Published: International Journal of Molecular Sciences. 2023; 24(24):17231

2023 | Cryopreservation | Journal Articles

Opposing roles for TGFβ- and BMP-signaling during nascent alveolar differentiation in the developing human lung

Authors: JR, AS, Y., Frum, Zhang, Clark, T., CJ, SG, Hsu, Utter, Glass, PP, OR, I., Hein, Anand, Sexton, JZ, R.F.C., A., Spence, Conchola, Zhang

Published: npj Regenerative Medicine, 2023;8:48

2023 | Cryopreservation | Journal Articles

Pharmacological rescue of mitochondrial and neuronal defects in SPG7 hereditary spastic paraplegia patient neurons using high throughput assays.

Authors: Wali G, Li Y, Liyanage E, Kumar KR, Day ML, Sue CM

Published: Frontiers in Neuroscience, 2023;17:1231584

2023 | Cryopreservation | Journal Articles

Phase 1 study to determine the safety and dosing of autologous PBMCs modified to present HPV16 antigens (SQZ-PBMC-HPV) in HLA-A*02+ patients with HPV16+ solid tumors

Authors: A., J.C., J. Miselis, Leal, Zwirtes, A., Jimeno, Moser, Mita, N.R., A.D., R.F., A., J.C., M., Ji, Neupane, Baranda, Butler, Gordon, R-R, P. Eng, J., M., M.S., Nair, C., Iams, Loughhead, Taylor, N., Yeku, Bernstein, O., J.W., S.M., M. Dhani, Kornacker, H., Mita, Park, Jennings, N., M., Sharei

Published: Investigational New Drugs, 2023

2023 | Cryopreservation | Journal Articles

Refrigerated human mesenchymal stromal cells as an alternative to cryostorage for use in clinical investigation

Authors: TC, Christy, Cap, BA, AP, Herzig, Bynum, MC, JA, Abaasah, IE, Heard

Published: Transfusion. 2023; 63(7): 1366–1375

2023 | Cryopreservation | Journal Articles

Safety and Preliminary Efficacy of Mesenchymal Stromal Cell (ORBCEL-M) Therapy in Diabetic Kidney Disease: A Randomized Clinical Trial (NEPHSTROM)

Authors: BA, P., V., T., O., for the NEPHSTROM Trial Consortium., Smythe, Perico, Ruggenenti, Maxwell, Griffin, Villa, Golay, J., N., PL, AP, TP, A., Fibbe, Remuzzi, Rota, Casiraghi, Islam, Todeschini, WE, G., S., F., MN, M., Elliman, Griffin, Cappelletti, Rubis, Introna, Carrara, J., SJ, F., MD., L., N., M., O'Brien, Finnerty, Magee, Cockwell, McInerney, Peracchi, Pedrini, T., AA

Published: Journal of the American Society of Nephrology, 2023;34(10):1733-1751

2023 | Cryopreservation | Journal Articles

SARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes

Authors: E., AR, RH, YP, Wall, Crowe, Holt, Georgiev, Binshtein, SC, JE Jr, CM, IS, E., Suryadevara, Thompson-Arildsen, Irbe, Chen, N., Ma, EB, EC, Kim, Sheward, Wasdin, Zost, SJ, C., DJ, PT, Canfield, Shiakolas, Carnahan, Suresh

Published: Cell Reports Medicine, 2023;Nov 21;4(11):101267

2023 | Cryopreservation | Journal Articles

Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB-CD8+ memory T cells and accumulation of type 2 memory T cells

Authors: P., E., S., Terekhova, Chernyatchik, Arthur, Sukhov, M., R., L., V., Swain, Husarcikova, Laha, Kleverov, A., K., A., D., Bohacova, Artyomov, Mogilenko, Echalar, B., P., MN, DA, Tsurinov, Aladyeva, Burdess

Published: Immunity, 2023;Nov 5:S1074-7613(23)00453-3

2023 | Cryopreservation | Journal Articles

Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance

Authors: A.G., N., J., L., B.W., Danielli, Gürgen, Zellinger, Bühlmann, Marques, S.G., D., M.J., P., J.G., Porpiglia, Delattre, Bechtold, Blau, Kasper, E., O., I., H.M., S., De Micheli, Surdez, Kisele, Wachtel, Bode, P.K., A.J., D., S., M., Henssen, Navarro, Roma, Volken, Schäfer

Published: Science Advances, 2023:9:6

2023 | Cryopreservation | Journal Articles

Single-cell transcriptomes reveal a molecular link between diabetic kidney and retinal lesions

Authors: Y., Z., Xu, Huang, Liu, Y., S., Z., Xiang, Qin, Z., W., Weigao, Yang, E., J., Lang, Chen

Published: Commununications Biology, 2023;6:912

2023 | Cryopreservation | Journal Articles

T-cell engineered with a fully humanized B-cell maturation antigenspecific T-cell antigen coupler receptor effectively target multiple myeloma

Authors: C.W., B., D.L., Bezverbnaya, Bramson, Groisman, Rill, K., J.L., B., D., Hammill, Baker, Xu, J.A., C.L., S.X., Cummings, Aarts, Bader, A.G., D., C., Helsen, Bojovic, Hayes

Published: Cytotherapy, 2023:25:490-501

2023 | Cryopreservation | Journal Articles

Therapeutic effect of adipose-derived mesenchymal stem cells in a porcine model of abdominal sepsis

Authors: S.G., S., Vélez-Pinto, Villarejo‑Campos, Guadalajara, J.F., P., H., Garcia-Arranz, García‑Hernández, Moraleda, M., A.M., J.M., García-Bernal, Vega‑Clemente, García‑Olmo, D., D., L., Gómez‑Heras, Jiménez‑Galanes

Published: Stem Cell Research & Therapy, 2023; 14, 365

2023 | Cryopreservation | Journal Articles

Unlocking the potential of allogeneic Vδ2 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR/IL-15 engineering

Authors: X., CJ, P., Z., Lee, de Li, Penn, Yang, Ma, D., Y-R, NE, L., F., Dunn, Zhou, Yu, Li, Z.S., JJ, Y., M., Guo, Pellegrini, Zhou, Song, T-C, W., M., K., Cen, Rosenthal, Wang, Li

Published: Nature Communications, 2023;14:6942

2022 | Cryopreservation | Journal Articles

A genetically engineered, stem-cell-derived cellular vaccine

Authors: R.K., E., T., V., Cooper, Gam, Chakraborty, and Barouch, Manickam, A, R., K., D.H., C., Sidaway, Arthofer, Yu, Kroll, A., E., J., K., Chandrashekar, Choudhry, McMahan, Mosher, M., A., M., K., Reeves, Latta, Henley, Giffin

Published: Cell Reports Medicine. 2022, 3:100843

2022 | Cryopreservation | Journal Articles

Cell Therapy with Human Reprogrammed CD8+ T-Cells Has Antimetastatic Effects on Lewis Lung Carcinoma in C57BL/6 Mice

Authors: and Dygai, Zhukova, Kogai, Skurikhin, A., M., L., E.G., Pan, Kushlinskii, Pershina, E., N., O.; Ermakova, Sandrikina, Kubatiev, N., L., A., Morozov, Pakhomova, Widera, S.G., A., D.

Published: International Journal of Molecular Sciences, 2022:23:15780

2022 | Cryopreservation | Journal Articles

Comparison of adhesion of thawed and cultured synovial mesenchymal stem cells to the porcine meniscus and the relevance of cell surface microspikes

Authors: Y., K., Fujii, Kohno, Koga, S., Y., H. and Sekiya, Endo, Mizuno, I., K., M., Ozeki, Katano, N., H., Sakamaki, Tsuji

Published: BMC Molecular and Cell Biology, 2022:23:53

2022 | Cryopreservation | Journal Articles

Cryopreserved anti-CD22 and bispecific anti-CD19/22 CAR T cells are as effective as freshly infused cells

Authors: B., N.N., Dreyzin, Highfill, A., S.L., Panch, Jin, S.R., P., Shalabi, Stroncek, H., D., Yates, and Shah

Published: Molecular Therapy: Methods & Clinical Development, 2023:28:51

2022 | Cryopreservation | Journal Articles

Development of a personalized dendritic cell vaccine and single-cell RNA sequencing-guided assessment of its cell type composition

Authors: J., R., Li, Li, Ding, Q, P., P., Yang, Zhu, Bai, C., X., P., Tian, Lei, Li, Q., H., T., Jiang, Yin

Published: Cytotherapy, 2023:25:210-219

2022 | Cryopreservation | Journal Articles

Efficient Induction of Antigen-Specific CD8+ T-Cell Responses by Cationic Peptide-Based mRNA Nanoparticles

Authors: S.D., D’haese, Vanham, S., G., Laeremans, Aerts, T., J.L., den Roover, S., Allard

Published: Pharmaceutics. 2022, 14, 1387

2022 | Cryopreservation | Journal Articles

Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus

Authors: X., J.R., E.K., M.I., A.M., Aliota, O’ConnorI, Mejia, Raasch, Noguchi, Shepherd, Alberts, Breitbach, Antony, M.T., D.H., A., L.E., K.K., P.M., A.J., M.E., Mohr, Dudley, Basu, Yamamoto, Morgan, Razo, Havlicek, Sneed, E.L., D.M., P., K., T.K., E., S.J., E.L., Friedrich, Simmons, Newman, Fuhler, Crooks, Kabakov, Weiler, T.C., K.M., H.A., A.M., C.M., N.A., C.M., S., Eickhoff, Golos, Ausderau, Zeng, Rosinski, Böhm, Bliss, Mitzey, J.C., T.G., K.K.

Published: PLOS Neglected Tropical Diseases. 2022, 16(8): e0010623

2022 | Cryopreservation | Journal Articles

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

Authors: A.M., M.E., K.K., N.P., S., Nork, O’Connor, Mejia, Pritchard, Friedrich, Rosinski, Sneed, Shepherd, Morgan, Bliss, Ausderau, T.M., D.H. &, A., J.C., T.C., J.R., E.L., P.M., T.K., M.I., Katz, Newman, Basu, Spanton, Aliota, Raasch, Fuchs, Yamamoto, Alberts, Richardson, M.T., A.W., C.M., P., R.V, L.E., K.B., K., A.J., A.D., Mohr, Rasmussen, Simmons, Ver Hoove, Tiburcio, Zeng, Razo, Antony, Einwalter, E.L., C.A., K.K., H.A., J.N., M.A., P.B., X., E., K.M., Kim, Dudley, Hartman, Böhm, Eickhoff, Weiler, Breitbach, Noguchi, Krabbe, Kabakov, C.B.Y., D.M., A., E.K., J.C.

2022 | Cryopreservation | Journal Articles

Frozen for combat: Quality of deep-frozen thrombocytes, produced and used by The Netherlands Armed Forces 2001–2021

Authors: R., Noorman, F., Rijnhout, T.W.H., de Kort, B., Hoencamp

Published: Transfusion. 2022, 1–14

2022 | Cryopreservation | Journal Articles

Generation and Characterization of Three Induced Pluripotent Stem Cells Lines from an 86-Year Old Female Individual Diagnosed with an Invasive Lobular Mammary Carcinoma

Authors: S., K., Keller, Weiss, Schmees, A-L., M., C., Greis, Koch, D., A., Eybe, Brucker, J., S.Y., Plöger, Schenke-Layland

2022 | Cryopreservation | Journal Articles

Impact of cryopreservation on CAR T production and clinical response

Authors: A., R. and Besser, Brezinger-Dayan, Zeltzer, M.J., K., L., Itzhaki, Jacoby, O., E., Melnichenko, Avigdor, J., A., Kubi, Shapira Frommer

Published: Frontiers in Oncology. 2022, 12:1024362

2022 | Cryopreservation | Journal Articles

In Vitro Drug Screening Using iPSC-Derived Cardiomyocytes of a Long QT-Syndrome Patient Carrying KCNQ1 & TRPM4 Dual Mutation: An Experimental Personalized Treatment

Authors: J., L., Y., Y., Wang, Lu, Liang, Zhang, F., Y., X., J., Han, Zhou, Wang, Zhang, Y., X., L., L., Sang, Tang, Xing, Zukela, T., W., B., Q., Xiaokereti, Wang, and Li, Guo

Published: Cells. 2022, 11: 2495

2022 | Cryopreservation | Journal Articles

Inferring and perturbing cell fate regulomes in human brain organoids

Authors: F., M., Fleck, Seimiya, He, J.S., M., Z., Jansen, Jain, Camp, S.M.J., A., J.G. & Treutlein, Wollny, Okamoto, B., D., R., Zenk, Santel

Published: Nature. 2022, 1476-4687

2022 | Cryopreservation | Journal Articles

Intraglandular mesenchymal stem cell treatment induces changes in the salivary proteome of irradiated patients

Authors: A., S.B., M., Lynggaard, Belstrøm, Grønhøj, Herly, C.D., D. & von Buchwald, C., M., Jersie-Christensen, C., Melchiors, Ekblond, R., J., A., Juhl, Jacobsen, Kastrup, J., M., S., Fischer-Nielsen, Jensen, Møller-Hansen

Published: Comminciations Medicine, 2022:2:160

2022 | Cryopreservation | Journal Articles

LC-MS/MS-based serum proteomics reveals a distinctive signature in a rheumatoid arthritis mouse model after treatment with mesenchymal stem cells

Authors: H., Jung, Seo, N., W.M., Park, Lee, S., S., Kong, Kang, T., K-S, Park

Published: PLoS ONE. 2022, 17(11): e0277218.

2022 | Cryopreservation | Journal Articles

Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques

Authors: J.D., L.K., Jr., J.E., Sureshchandra, Goldman, Nash, C.T., Takahashi, S., D., M.J., Burwitz, D., Chan, Packwood, Wesolowski, B.J., Shen, C.N., W., S.R., Messaoudi, W., Robino, Lindner, Pietras, I., Jiang, X., J.J., J.R., E.M., and Varlamov, Hennebold, Parmelee, Roberts, Friedman, O.

Published: Stem Cell Reports. 2022, 17 :1–15

2022 | Cryopreservation | Journal Articles

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

Authors: E., H.H.M., K.M., J.W., C.K., Amatngalim, Brunsveld, Aarts, Heijerman, Silva, Beekman, G.D., J.E., E.M., H.G., I.A., Rodenburg, van Drunen, Sarhane, Kapitein, Nijenhuis, L.W., C.M., D., L.C., W., Aalbers, Michel, Spelier, Amaral, Vrendenbarg, J.M., S., B.L., S., S., M.D., Kruisselbrink, Raeven, de Winter-de Groot, Lefferts, van der Ent

Published: Life Science Alliance. 2022, 5:12, e202101320

2022 | Cryopreservation | Journal Articles

Optimizing an immunomodulatory potency assay for Mesenchymal Stromal Cell

Authors: Hansen SB, Højgaard LD, Kastrup J, Ekblond A, Follin B and Juhl M

Published: Frontiers in Immunology, 2022,13:1085312

2022 | Cryopreservation | Journal Articles

Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models

Authors: E., T., D., K., Yang, Cook, Honaker, Rawlings, Mauk, S.J., P.J., Y., D.J., K., Singh, Sommer, Barahmand-Pour-Whitman, Buckner, Xiang, A.K., K., F., J.H., Y., Drow, Khan, Linsley, Smith, J., T., I., P.S., Mortensen, Tappen, Liggitt, Cerosaletti

Published: Science Translational Medicine. 2002, 14:665, eabn1716

2022 | Cryopreservation | Journal Articles

Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation

Authors: C., M., D., J., Proics, Grossi, Lounnas-Mourey, Levings, Bastian, E., M., N., M.K., H., David, Heimendinger, Govehovitch, Meyer, Freschi, M., P., A., F., L., Mojibian, Abel, Baghdadi, and Dumont, Privat, G., M., T., W., C., Pouzet, Speck, Fenard, Desnouveaux

Published: Gene Therapy. 2022

2022 | Cryopreservation | Journal Articles

Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

Authors: L., Möller, Kissling, L., L., Aird, van de Venn, E.J., L., Schröder, & Corn, M.S., J.E., Kobel

Published: Nature Communications. 2022, 13:4550

2022 | Cryopreservation | Journal Articles

Reduced peripheral blood dendritic cell and monocyte subsets in MDS patients with systemic inflammatory or dysimmune diseases

Authors: S., F., B., A., L., Jachiet, Banos, Pascal, Durot, Vey, V., A., L., E., N., Ricard, Wickenhauser, Beyne-Rauzy, Natarajan-Ame, D'Aveni, L., S., O., S., M., Hirsch, Terriou, Peterlin, Vekhoff, Gourin, M. P., P., L., P., A., Dimicoli-Salazar, Malard, De Renzis, Maria, Voillat

Published: Clinical and Experimental Medicine. 2022, 10:1007

2022 | Cryopreservation | Journal Articles

Robust Generation of Ready-to-Use Cryopreserved Motor Neurons from Human Pluripotent Stem Cells for Disease Modeling

Authors: H-J, Ting, Lin, H-C, S-Z, Su, Chiou, H-L, T-W and Chang, Chen, C-Y, M-F, Harn

Published: International Journal of Molecular Sciences. 2022, 23, 13462

2022 | Cryopreservation | Journal Articles

Stem-like memory T cells are generated during hollow fiber perfusion- based expansion and enriched after cryopreservation in an automated modular cell therapy manufacturing process

Authors: D., Cunningham, Miller, A.W., M.M., Jones, M., Frank, N., Sethi

Published: Cytotherapy, 2022;24:1148-1157

2022 | Cryopreservation | Journal Articles

Stem-like memory T cells are generated during hollow fiber perfusion-based expansion and enriched after cryopreservation in an automated modular cell therapy manufacturing process

Authors: D, Cunningham, Miller, A.W., M.M., Jones, M., Frank, N., Sethi

Published: Cytotherapy. 2022, 24;1148-1157

2022 | Cryopreservation | Journal Articles

Systematic Single Cell Pathway Analysis (SCPA) reveals novel pathways engaged during early T cell activation

Authors: N.R., N., F., Bibby, Merle, Mukherjee, J.A., N.S., S., Agarwal, West, Afzali, D., E.E., B., Freiwald, Larochelle, Kemper, C., T., A., Zhang, Kunz, Chinian

2022 | Cryopreservation | Journal Articles

Titration of 124 antibodies using CITE-Seq on human PBMCs

Authors: R., K., Nettersheim, Roy, F.S., P., Armstrong, Orecchioni, S.S., M., Durant, Suryawanshi, C., V, Blanco‑Dominguez, Ley

Published: Scientific Reports. 2022, 12:20817